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KMID : 0365719920080010021
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Journal of Pusan Surgical Society
1992 Volume.8 No. 1 p.21 ~ p.34
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A Study on T Cell Subset and Natural Killer (NK) of Peripheral Blood on Patients with Stomach Cancer
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Abstract
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To elucidate alteration of peripheral T cell susbsets and NK cells in patients with stomach cancer, the authors examined CD3+, CD4+, and Leu 7+ cells and NK cell activity in 25 cases of preoperative patients and 26 cases of postoperative patients
with
stomach cancer as well as 23 cases of adult healthy subjects as control.
Diagnoses were confirmed histopathologically in all the patients. All blood samples were obtained from veins of the patients and control subjects on Pusan national University hospital during the Period of January of August. 1990.
@ES The results obtained were summarized as follows :
@EN 1) The percentage of CD4+ cells and CD4/CD8 ratio were significantly decreased in the preoperative patients with the stage IV in stomach cancer as compared with adult healthy subjects and the stage I + II or stage III respectively, and tended
to be
decreased as the stage was advanced.
2) The percentage of CD8+ cells was significantly increased in the preoperative patients with the stage IV oin stomach cancer as compared with adult healthy subjects, and the stage I + II or stage III respectively.
3) The percentage of Leu 7+ cells was not different between the adult healthy subjects and the preoperative patients in al stages of stomach cancer.
4) The activity of NK cells was significantly decreased in the preoperative patients on all stages of stomach cancer, and tended to be decreased as the stage was advanced.
5) The percentage of CD4+, CD8+, and Leu 7+ cells and the activety of NK cells were not different between the preoperative and postoperative patients in all stages of stomach cancer.
On the basis of this results, it can be suggested that the cellular immunosuppression in the preoperative patients with advanced stomach cancer is due to the decreased helper/inducer T cells and increased supressor/cytotoxic T cell. and that the
activity of NK cells is decreased on all the patients with stomach cancer.
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KEYWORD
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